Thioglycolic Acid → 2-(But-3-ynylthio)acetic acid

HRID 129306Notes

Reaction equation

[CH2:1]([SH:5])[C:2]([OH:4])=[O:3].CS(O[CH2:11][CH2:12][C:13]#[CH:14])(=O)=O>>[CH2:14]([S:5][CH2:1][C:2]([OH:4])=[O:3])[CH2:13][C:12]#[CH:11]

Participants

Reactant 2

HCID 1133Thioglycolic Acid

HCID 11378578But-3-yn-1-yl methanesulfonate

Product 1

HCID 193732562-(But-3-ynylthio)acetic acid

Procedure

2-(But-3-ynylthio)acetic acid was prepared from thioglycollic acid and but-3-ynyl methanesulphonate using the methodology described in stage (i) of Example XIII.

Sources & evidence

ORD record: ord-f13c293f48b3430ebb0fd5f3f0164cc1
Source dataset: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05466710

Reaction notes

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