Water → HCID 17838758, compound

Participants

Reaction Steps

A suspension of 3-benzylthio-1H-1,2,4-triazole (172 mg), dimethylcarbamoyl chloride (248 μl) and anhydrous potassium carbonate (621 mg) in dimethylformamide (4 ml) was stirred at room temperature for 80 minutes. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed three times with water and subsequently once with saturated aqueous sodium chloride solution, and then dried over sodium sulfate. After filtration, the solvent was distilled from the filtrate under reduced pressure to obtain a clear oil. The resultant oil was purified by a column chromatography (ethyl acetate/hexane=1/5) to yield the titled compound (88 mg) as a clear oil.

Provenance & Evidence