Dimethylcarbamoyl Chloride → HCID 17838728, compound

Participants

Reaction Steps

To a mixture of 3-(2,4,6-trimethylphenyl)thio-1H-1,2,4-triazole (220 mg), anhydrous potassium carbonate (280 mg) and N,N-dimethylformamide (1 ml) was added N,N-dimethylcarbamoyl chloride (0.14 ml), and the reaction mixture was stirred at room temperature for 2 hours. The reaction solution was extracted with ethyl acetate-water. The organic layer was washed with water, followed by saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to a silica-gel column chromatography with 10 to 15% (20% 2-propanol/ethyl acetate)/hexane to yield the title compound (276 mg).

Provenance & Evidence