Ethyl Acetate → HCID 17838729, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-(2,4,6-trimethylphenyl)thio-1-dimethylcarbamoyl-1H-1,2,4-triazole (Example 32) (226 mg) and ethyl acetate (1 ml) was added m-chloroperbenzoic acid (360 mg), and the reaction mixture was heated and stirred for 4 hours on an oil bath at 60° C. To the reaction solution were added 1 M aqueous sodium thiosulfate solution (0.1 ml) and 5 M aqueous potassium carbonate solution (0.25 ml), and the mixture was extracted with ethyl acetate-water. The organic layer was washed with saturated aqueous sodium chloride solution and concentrated. The residue was dissolved in ethyl acetate with heating. The solution was filtered through a small amount silica gel, which was washed with ethyl acetate, and concentrated under reduced pressure. The residue was crystallized in ethyl acetate-hexane to yield the title compound (178 mg).

Provenance & Evidence