Pyridine → HCID 9945706, compound

Participants

Reaction Steps

Triphosgene (20 mg) was dissolved in dichloromethane (1 ml). To this solution was added pyridine (0.017 ml) with cooling it on an ice-water bath, and the reaction mixture was stirred for 5 minutes. Then, 3-(2,4,6-trimethylphenyl)sulfonyl-1H-1,2,4-triazole (Example 35-a) (51 mg) was added, and stirred for additional 10 minutes. Then, N-methylethylamine (0.034 ml) was added, and the reaction mixture was stirred at room temperature for 6 hours. The reaction solution was subjected to a silica-gel column chromatography with 50% ethyl acetate/hexane to yield the title compound (52 mg).

Provenance & Evidence