Potassium Hydroxide → HCID 178473690, compound

Participants

Reaction Steps

To a solution of potassium hydroxide (13 g) in methanol (200 ml), with cooling it on ice, was added 3-mercapto-1H-1,2,4-triazole (20 g), followed by 3-chloro-2,4-pentanedione (24 ml). Then, mixture was stirred at room temperature overnight. Insoluble materials in the reaction solution were filtered off, and the filtrate was concentrated under reduced pressure. The residue was extracted with ethyl acetate-water. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then filtered through a small amount of silica gel, which was washed with ethyl acetate. The filtrate was concentrated under reduced pressure. The residue was recrystallized in ethyl acetate-hexane to yield the title compound (33.1 g).

Provenance & Evidence