Hydrochloric Acid → 3-(2-methylimidazo[1,2-a]pyridin-3-yl)sulfonyl-1H-1,2,4-triazole

Participants

Reaction Steps

To a mixture of 3-(2-methylimidazo[1,2-a]pyridin-3-yl)thio-1H-1,2,4-triazole (Example 50-a) (230 mg), acetonitrile (5 ml) and water (5 ml) was added sodium percarbonate (630 mg) in small portions on a water bath at 30° C. At this temperature the reaction mixture was stirred for 4 hours. To the reaction solution was added water (7.5 ml), and then concentrated hydrochloric acid was added dropwise on an ice bath, followed by adjusting the pH to about 4. The reaction mixture was stirred as it was for 30 minutes, and precipitated crystals were collected by filtration, washed with water, and dried to the title compound (139 mg).

Provenance & Evidence