Potassium Carbonate → HCID 178419394, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-mercapto-1H-1,2,4-triazole (200 mg), 2,6-dibromopyridine (560 mg), anhydrous potassium carbonate (420 mg) and N,N-dimethylformamide (1 ml) was heated and stirred for 3 hours on an oil bath at 100° C. The reaction solution was extracted with ethyl acetate-water. The organic layer was washed with water, followed by saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by a silica-gel column chromatography with 5 to 30% (20% 2-propanol/ethyl acetate)/hexane to yield the title compound (73 mg).

Provenance & Evidence