Dimethylcarbamoyl Chloride → HCID 17838721, compound

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Reaction Steps

A mixture of 3-(6-bromo-2-pyridyl)thio-1H-1,2,4-triazole (73 mg), dimethylcarbamoyl chloride (40 μl), anhydrous potassium carbonate (80 mg) and N,N-dimethylformamide (0.5 ml) was stirred at room temperature for 2 hours. The reaction solution was extracted with ethyl acetate-water. The organic layer was washed with water, followed by saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by a silica-gel column chromatography with 20% (20% 2-propanol/ethyl acetate)/hexane to yield the title compound (77 mg).

Provenance & Evidence