1,4-Dioxane hydrochloride → HCID 178465286, compound

Participants

Reaction Steps

To 100 mg (0.30 mmol) of the product of Step A [1-(5-phenyl-2H-pyrazol-3-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester was added 1 ml of 4N HCl dioxane solution (Aldrich) at ambient temperature. The reaction was allowed to stir for 3 hours. After evaporation to dryness and trituration with ether, 73 mg of amino-N-(5-phenyl-2H-pyrazol-3-yl)-propionamide dihydrochloride was obtained as a white powder (80%) (MS: 231[P+1]/229 [P−1])(RF=0.2 on silica TLC (9/1 Chloroform/Methanol).

Provenance & Evidence