反应详情

Eletriptan hydrobromide (4.91 g) was dissolved in a mixture of acetone (10 ml) and water (1.85 ml) by heating under reflux. The mixture was treated with acetone (63.6 ml), dropwise over about 20 minutes, and then cooled to ambient temperature. The mixture was granulated overnight (16 hours), cooled to 0–5° C. and granulated at this temperature for a further hour. The resulting solid was filtered, washed with acetone (3 ml) and then dried under reduced pressure and at ambient temperature to give eletriptan hydrobromide monohydrate (4.8 g).

1. temperatureby heating
2. temperatureunder reflux
3. temperature(16 hours), cooled to 0–5° C.
4. waitgranulated at this temperature for a further hour
5. filtrationThe resulting solid was filtered
6. washwashed with acetone (3 ml)
7. customdried under reduced pressure and at ambient temperature