Eletriptan hydrobromide monohydrate → Eletriptan Hydrobromide

HRID 1293157Notes

Reaction equation

HRID 1293157 reaction equation
[CH3:1][N:2]1[C@@H:6]([CH2:7][C:8]2[C:12]3[CH:13]=[C:14]([CH2:17][CH2:18][S:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)(=[O:21])=[O:20])[CH:15]=[CH:16][C:11]=3[NH:10][CH:9]=2)[CH2:5][CH2:4][CH2:3]1.O.[BrH:29]>CC(C)=O>[CH3:1][N:2]1[C@@H:6]([CH2:7][C:8]2[C:12]3[CH:13]=[C:14]([CH2:17][CH2:18][S:19]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)(=[O:20])=[O:21])[CH:15]=[CH:16][C:11]=3[NH:10][CH:9]=2)[CH2:5][CH2:4][CH2:3]1.[BrH:29]

Participants

3

Reactant 1

HCID 9891365Eletriptan hydrobromide monohydrate

Product 1

HCID 656631Eletriptan HydrobromideYield 92.4%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A slurry of eletriptan hydrobromide monohydrate (6.5 g) in acetone (97.5 ml) was heated under reflux for three hours and then cooled and filtered. The filtered solid was washed with acetone (6.5 ml) and dried under reduced pressure to give anhydrous eletriptan hydrobromide (5.78 g).

Workup

  1. temperatureunder reflux for three hours
  2. temperaturecooled
  3. filtrationfiltered
  4. washThe filtered solid was washed with acetone (6.5 ml)
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-98536a960dfb49dd9556727c3c8c37af
Source dataset
uspto-grants-2007_07
Patent number
US07238723B2

Reaction notes

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