反应详情

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorophenoxy)nicotinic acid (step 3 of Example 1) and methyl 4-(1-amino-1-methylethyl)benzoate: 1H-NMR (CDCl3) δ 8.33 (1H, br.s), 8.24 (1H, dd, J=8.2, 3.1 Hz), 8.04–7.99 (3H, m), 7.51 (2H, dd, J=6.7, 1.9 Hz), 7.18–7.16 (4H, m), 3.90 (3H, s), 1.80 (6H, s); MS (ESI) m/z 427 (M+H)+, 425 (M−H)−.