(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 57572275, compound

HRID 1293169Notes

Reaction equation

HRID 1293169 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][CH2:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][CH:21]=2)=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.Cl.N[C@H:32](C1C=CC(C(OC)=O)=CC=1)C>>[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][C@H:19]([C:20]2[CH:21]=[CH:22][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:28][CH:29]=2)[CH3:32])=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 57572271HCID 57572271, compound

Product 1

HCID 57572275HCID 57572275, compound

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorophenoxy)nicotinic acid (step 3 of Example 1) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3): 1H-NMR (CDCl3) the data of the title compound were identical with that of the racemate (step 2 of Example 2); MS (ESI) m/z 413 (M+H)+, 411 (M−H)−.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-189b905fce5645c89e01907520359973
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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