HCID 57555427, compound → HCID 57572272, compound

HRID 1293172Notes

Reaction equation

HRID 1293172 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][CH2:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][CH:21]=2)=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.N[CH2:31]C1C=CC(C(OC)=O)=CC=1C>>[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:28][C:29]=2[CH3:31])=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 57555427HCID 57555427, compoundHCID 57572271HCID 57572271, compound

Product 1

HCID 57572272HCID 57572272, compound

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorophenoxy)nicotinic acid (step 3 of Example 1) and methyl 4-(aminomethyl)-3-methylbenzoate: 1H-NMR (CDCl3) δ 8.36 (1H, dd, J=8.2, 3.1 Hz), 8.25–8.18 (1H, m), 8.04 (1H, d, J=3.1 Hz), 7.85–7.81 (2H, m), 7.37 (1H, d, J=7.7 Hz), 7.15–7.07 (4H, m), 4.73 (2H, d, J=5.8 Hz), 3.89 (3H, s), 2.40 (3H, s); MS (ESI) m/z 413 (M+H)+, 411 (M−H)−.

Sources & evidence

ORD record
ord-b788f3eda21b429ba75c6bf6a6090f24
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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