反应详情

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorophenoxy)nicotinic acid (step 3 of Example 1) and methyl 4-(aminomethyl)-3-methylbenzoate: 1H-NMR (CDCl3) δ 8.36 (1H, dd, J=8.2, 3.1 Hz), 8.25–8.18 (1H, m), 8.04 (1H, d, J=3.1 Hz), 7.85–7.81 (2H, m), 7.37 (1H, d, J=7.7 Hz), 7.15–7.07 (4H, m), 4.73 (2H, d, J=5.8 Hz), 3.89 (3H, s), 2.40 (3H, s); MS (ESI) m/z 413 (M+H)+, 411 (M−H)−.