tert-butyl 4-[(1S)-1-aminoethyl]benzoate → tert-Butyl 4-{(1S)-1-[({5-chloro-2-[(5-chloropyridin-3-yl)oxy]pyridin-3-yl}carbonyl)amino]ethyl}benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-[(5-chloropyridin-3-yl)oxy]nicotinic acid (step 1) and tert-butyl 4-[(1S)-1-aminoethyl]benzoate (step 3 of Example 44): 1H-NMR (CDCl3) δ 8.56 (1H, d, J=2.7 Hz), 8.55–8.54 (1H, m), 8.42–8.41 (1H, m), 8.13 (1H, d, J=2.7 Hz), 7.99–7.96 (2H, m), 7.80–7.82 (1H, m), 7.58 (1H, t, J=2.3 Hz), 7.42–7.39 (2H, m), 5.42–5.31 (1H, m), 1.62–1.58 (12H, m); MS (ESI) m/z 488 (M+H)+, 486 (M−H)−.

Provenance & Evidence