tert-butyl 4-[(1S)-1-aminoethyl]benzoate → tert-Butyl 4-[(1S)-1-({[5-chloro-2-(3-cyanophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-(3-cyanophenoxy)nicotinic acid (step 1) and tert-butyl 4-[(1S)-1-aminoethyl]benzoate (step 3 of Example 44): 1H-NMR (CDCl3) δ 8.56 (1H, d, J=2.7 Hz), 8.13 (1H, d, J=2.7 Hz), 7.98–7.95 (2H, m), 7.89–7.86 (1H, m), 7.64–7.38 (6H, m), 5.42–5.31 (1H, m), 1.61–1.58 (12H, m); MS (ESI) m/z 476 (M−H)−.

Provenance & Evidence