2,4-Difluorophenol → Methyl 4-[(1S)-1-({[5-chloro-2-(2,4-difluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 48 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 2,4-difluorophenol: 1H-NMR (CDCl3) δ 8.54 (1H, d, J=2.7 Hz), 8.11 (1H, d, J=2.7 Hz), 8.05–7.98 (3H, m), 7.44 (2H, d, J=8.6 Hz), 7.35–7.27 (1H, m), 7.06–6.93 (2H, m), 5.442–5.32 (1H, m), 3.90 (3H, s), 1.61 (3H, d, J=7.0 Hz); MS (ESI) m/z 447 (M+H)+, 445 (M−H)−.

Provenance & Evidence