Methyl 4-(aminomethyl)benzoate hydrochloride → Methyl 4-[({[5-fluoro-2-(4-fluorobenzyl)pyridin-3-yl]carbonyl}amino)methyl]benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorobenzyl)nicotinic acid (step 3) and methyl 4-(aminomethyl)benzoate hydrochloride: 1H-NMR (CDCl3) δ 8.49 (1H, d, J=2.8 Hz), 8.01–7.97 (2H, m), 7.44 (1H, dd, J=7.9, 2.8 Hz), 7.27 (2H, dd, J=4.6, 4.0 Hz), 7.14–7.09 (2H, m), 6.93–6.86 (2H, m), 6.08 (1H, br.s), 4.56 (2H, d, J=5.9 Hz), 4.29 (2H, s), 3.92 (3H, s); MS (ESI) m/z 397 (M+H)+, 395 (M−H)−.

Provenance & Evidence