(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → Methyl 4-[(1S)-1-({[5-fluoro-2-(4-fluorobenzyl)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorobenzyl)nicotinic acid (step 3 of Example 58) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 9.13 (1H, d, J=7.7 Hz), 8.59 (1H, d, J=3.0 Hz), 7.93 (2H, d, J=8.4 Hz), 7.79 (1H, dd, J=8.7, 2.8 Hz), 7.51 (2H, d, J=8.2 Hz), 7.15–7.09 (2H, m), 7.03–6.96 (2H, m), 5.19–5.09 (1H, m), 4.17 (1H, d, J=13.7 Hz), 4.08 (1H, d, J=13.7 Hz), 3.85 (3H, s), 1.42 (3H, d, J=7.1 Hz); MS (ESI) m/z 411 (M+H)+, 409 (M−H)−.

Provenance & Evidence