(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 57572318, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-(3-cyanobenzyl)nicotinic acid (step 2) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.58 (1H, d, J=2.4 Hz), 8.05–8.02 (2H, m), 7.66 (1H, d, J=2.4 Hz), 7.50–7.27 (6H, m), 6.01 (1H, d, J=8.1 Hz), 5.32–5.23 (1H, m), 4.30 (2H, s), 3.93 (3H, s), 1.54 (3H, d, J=7.0 Hz); MS (ESI) m/z 432 (M−H)−.

Provenance & Evidence