Methyl 4-(aminomethyl)benzoate hydrochloride → Methyl 4-({[5-chloro-2-(4-fluorophenoxy)benzoyl]amino}methyl)benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-(4-fluorophenoxy)benzoic acid (step 2) and methyl 4-(aminomethyl)benzoate hydrochloride: 1H-NMR (CDCl3) δ 8.24 (1H, d, J=2.8 Hz), 7.97–7.94 (3H, m), 7.36–7.32 (3H, m), 7.11–6.96 (4H, m), 6.74 (1H, d, J=8.8 Hz), 4.71 (2H, d, J=5.9 Hz), 3.90 (3H, s); MS (ESI) m/z 414 (M+H)+, 412 (M−H)−.

Provenance & Evidence