5-Chloro-2-(4-fluorophenoxy)benzoic acid → Methyl 4-({[5-chloro-2-(4-fluorophenoxy)benzoyl]amino}methyl)-2-fluorobenzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-(4-fluorophenoxy)benzoic acid (step 2 of Example 67) and methyl 4-(aminomethyl)-2-fluorobenzoate: 1H-NMR (CDCl3) δ 8.22 (1H, d, J=2.6 Hz), 8.06–7.98 (1H, m), 7.86 (1H, t, J=7.7 Hz), 7.35 (1H, dd, J=8.9, 2.6 Hz), 7.13–6.98 (6H, m), 6.75 (1H, d, J=8.9 Hz), 4.69 (2H, d, J=5.9 Hz), 3.91 (3H, s); MS (ESI) m/z 432 (M+H)+, 430 (M−H)−.

Provenance & Evidence