(4-(1H-1,2,3,4-tetrazol-5-yl)phenyl)methanamine hydrochloride → 5-Chloro-2-(4-fluorophenoxy)-N-[4-(2H-tetrazol-5-YL)benzyl]benzamide

HRID 1293230Notes

Reaction equation

HRID 1293230 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[N:20]1[NH:21][N:22]=[N:23][C:24]=1[C:25]1[CH:30]=[CH:29][C:28]([CH2:31][NH2:32])=[CH:27][CH:26]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[C:6]([CH:10]=1)[C:7]([NH:32][CH2:31][C:28]1[CH:27]=[CH:26][C:25]([C:24]2[N:20]=[N:21][NH:22][N:23]=2)=[CH:30][CH:29]=1)=[O:9]

Participants

3

Reactant 2

HCID 23224690(4-(1H-1,2,3,4-tetrazol-5-yl)phenyl)methanamine hydrochlorideHCID 457924105-Chloro-2-(4-fluorophenoxy)benzoic acid

Product 1

HCID 589053395-Chloro-2-(4-fluorophenoxy)-N-[4-(2H-tetrazol-5-YL)benzyl]benzamide

Procedure

The title compound was prepared according to the procedure described in Example 75 from 5-chloro-2-(4-fluorophenoxy)benzoic acid (step 2 of Example 67) and 1-[4-(2H-tetrazol-5-yl)phenyl]methanamine hydrochloride: 1H-NMR (DMSO-d6) δ 9.01 (1H, t, J=6.0 Hz), 7.93 (2H, d, J=8.2 Hz), 7.70 (1H, d, J=2.6 Hz), 7.53–7.46 (3H, m), 7.29–7.10 (4H, m), 6.93 (1H, d, J=8.9 Hz), 4.52 (2H, d, J=6.1 Hz); MS (ESI) m/z 424 (M+H)+, 422 (M−H)−.

Sources & evidence

ORD record
ord-f4e090ff8bae49438a82918e9251767b
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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