(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → Methyl 4-((1S)-1-{[5-(aminocarbonyl)-2-(3-fluorophenoxy)benzoyl]amino}ethyl)benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-(Aminocarbonyl)-2-(3-fluorophenoxy)benzoic acid (step 5) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.60 (1H, d, J=2.4 Hz), 8.05 (1H, dd, J=8.6, 2.4 Hz), 7.91 (2H, d, J=8.4 Hz), 7.83 (1H, d, J=7.2 Hz), 7.42–7.27 (3H, m), 7.00–6.77 (5H, m), 6.12 (1H, br.s), 5.32–5.22 (1H, m), 3.89 (3H, s), 1.51 (2H, d, J=7.0 Hz); MS (ESI) m/z 437 (M+H)+, 435 (M−H)−.

Provenance & Evidence