3-Chloro-o-cresol → methyl 4-[(1S)-1-({[5-chloro-2-(3-chloro-2-methylphenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

HRID 1293240Notes

Reaction equation

HRID 1293240 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:23])=[CH:4][N:3]=1.[Cl:24][C:25]1[C:26]([CH3:32])=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=1>>[Cl:23][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:31][C:27]2[CH:28]=[CH:29][CH:30]=[C:25]([Cl:24])[C:26]=2[CH3:32])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 148563-Chloro-o-cresolHCID 86601543Methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69418363methyl 4-[(1S)-1-({[5-chloro-2-(3-chloro-2-methylphenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 3-chloro-2-methylphenol: 1H-NMR (CDCl3) δ 8.57 (1H, dd, J=2.6, 0.7 Hz), 8.18–7.99 (4H, m), 7.44–7.34 (3H, m), 7.23 (1H, d, J=8.1 Hz), 7.02 (1H, d, J=8.1 Hz), 5.45–5.35 (1H, m), 3.90 (3H, s), 2.19 (3H, s), 1.60 (3H, d, J=6.9 Hz); MS (ESI) m/z 459 (M+H)+, 457 (M−H)−.

Sources & evidence

ORD record
ord-168a7859201742cd8593729091ed0da6
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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