3-(Pyridin-2-yl)phenol → Methyl 4-[(1S)-1-({[5-chloro-2-(3-pyridin-2-ylphenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 3-pyridin-2-ylphenol (Chem. Pharm. Bull. 1985, 33, 1009): 1H-NMR (CDCl3) δ 8.71–8.68 (1H, m), 8.56 (1H, d, J=2.8 Hz), 8.22 (1H, d, J=7.4 Hz), 8.13 (1H, d, J=2.8 Hz), 8.02–7.99 (2H, m), 7.92–7.81 (2H, m), 7.79–7.76 (2H, m), 7.57 (1H, t, J=7.9 Hz), 7.44 (2H, d, J=8.2 Hz), 7.30–7.20 (2H, m), 5.43–5.33 (1H, m), 3.89 (3H, s), 1.60 (3H, d, J=6.9 Hz); MS (ESI) m/z 488 (M+H)+, 486 (M−H)−.

Provenance & Evidence