3-(Pyridin-3-yl)phenol → HCID 69416070, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 3-pyridin-3-ylphenol (J. Med. Chem. 1981, 24, 1475): 1H-NMR (CDCl3) δ 8.86 (1H, d, J=1.8 Hz), 8.63 (1H, dd, J=4.8, 1.5 Hz), 8.57 (1H, d, J=2.6 Hz), 8.17–8.15 (2H, m), 8.02–7.99 (2H, m), 7.90–7.86 (1H, m), 7.62–7.36 (6H, m), 7.22–7.18 (1H, m), 5.45–5.34 (1H, m), 3.89 (3H, s), 1.61 (3H, d, J=6.9 Hz); MS (ESI) m/z 488 (M+H)+, 486 (M−H)−.

Provenance & Evidence