80653-80-1 → HCID 69416993, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 3-pyridin-4-ylphenol (J. Heterocycl. Chem. 1991, 28, 933): 1H-NMR (CDCl3) δ 8.69 (2H, dd, J=4.4, 1.6 Hz), 8.57 (1H, d, J=2.8 Hz), 8.15 (1H, d, J=2.6 Hz), 8.12 (1H, br.s), 8.00 (2H, dd, J=6.8, 1.9 Hz), 7.61–7.42 (7H, m), 7.27–7.22 (1H, m), 5.45–5.34 (1H, m), 3.89 (3H, s), 1.61 (3H, d, J=6.9 Hz); MS (ESI) m/z 488 (M+H)+, 486 (M−H)−.

Provenance & Evidence