2,3-Dimethylphenol → HCID 69418638, compound

HRID 1293247Notes

Reaction equation

HRID 1293247 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:23])=[CH:4][N:3]=1.[CH3:24][C:25]1[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][C:26]=1[OH:32]>>[Cl:23][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:32][C:26]2[CH:27]=[CH:28][CH:29]=[C:30]([CH3:31])[C:25]=2[CH3:24])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 106872,3-DimethylphenolHCID 86601543Methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69418638HCID 69418638, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 2,3-dimethylphenol: 1H-NMR (CDCl3) δ 8.56 (1H, d, J=3.0 Hz), 8.32 (1H, d, J=7.4 Hz), 8.11 (1H, d, J=2.8 Hz), 8.02–7.99 (2H, m), 7.43 (2H, d, J=8.4 Hz), 7.23–7.13 (2H, m), 6.95 (1H, d, J=7.7 Hz), 5.46–5.36 (1H, m), 3.90 (3H, s), 2.35 (3H, s), 2.05 (3H, s), 1.59 (3H, d, J=6.9 Hz).

Sources & evidence

ORD record
ord-e62bcb2eda17485083e5b9f2d80b59dc
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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