Hydrochloric Acid → HCID 69417491, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 83 from methyl 4-((1S)-1-{[(5-chloro-2-{4-[2-(dimethylamino)ethyl]phenoxy}pyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1) and then converted into the hydrochloride salt with 4 M solution of hydrogen chloride in ethyl acetate: 1H-NMR (DMSO-d6) δ 9.04 (1H, d, J=7.9 Hz), 8.26 (1H, d, J=2.8 Hz), 8.12 (1H, d, J=2.6 Hz), 7.85 (2H, d, J=8.4 Hz), 7.53 (2H, d, J=8.3 Hz), 7.34 (2H, d, J=8.6 Hz), 7.17 (2H, d, J=8.6 Hz), 5.22–5.12 (1H, m), 3.29–3.25 (2H, m), 3.04–2.99 (2H, m), 2.80 (6H, s), 1.45 (3H, d, J=7.0 Hz); MS (ESI) m/z 468 (M+H)+, 466 (M−H)−.

Provenance & Evidence