4-Chlorophenol → 4-[(1S)-1-({[5-Chloro-2-(4-chlorophenoxy)pyridin-3-YL]carbonyl}amino)ethyl]benzoic acid

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Reaction Steps

The title compound was prepared according to the two steps procedure described in step 2 and 3 of Example 45. Firstly, tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) was reacted with 4-chlorophenol. Next, the crude product was converted to the corresponding carboxylic acid: 1H-NMR (CDCl3) δ 8.55 (1H, d, J=2.8 Hz), 8.14 (1H, d, J=2.8 Hz), 8.11–8.02 (3H, m), 7.50–7.39 (4H, m), 7.11 (2H, d, J=9.0 Hz), 5.44–5.31 (1H, m), 1.60 (3H, d, J=7.0 Hz); MS (ESI) m/z 431 (M+H)+, 429 (M−H)−.

Provenance & Evidence