HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxy-5-chloropyridine → 5-Chloro-2-[(5-chloropyridin-3-yl)oxy]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxy-5-chloropyridine | HCID 582305 | — |
| Reactant | Methyl 5-chloro-2-fluorobenzoate | HCID 21525433 | — |
| Product | 5-Chloro-2-[(5-chloropyridin-3-yl)oxy]benzoic acid | HCID 64600393 | — |
Reaction Steps
The title compound was prepared according to the two steps procedure described in step 1 of Example 67 and step 2 of Example 99. Firstly, methyl 5-chloro-2-fluorobenzoate was reacted with 5-chloropyridin-3-ol. Next, the crude product was hydrolyzed to the corresponding carboxylic acid: 1H-NMR (DMSO-d6) δ 8.36 (1H, d, J=2.0 Hz), 8.25 (1H, d, J=2.4 Hz), 7.87 (1H, d, J=2.6 Hz), 7.70 (1H, dd, J=8.8, 2.6 Hz), 7.50 (1H, dd, J=2.4, 2.0 Hz), 7.29 (1H, d, J=8.8 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07238714B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-8288a522235840e9a9e7552e2ccde438 |
| Source note | uspto-grants-2007_07 |