4-Chlorobenzenesulfonamide → 5-Chloro-N-{(1S)-1-[4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}-2-(4-fluorophenoxy)nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	4-Chlorobenzenesulfonamide	HCID 66824	—
Reactant	4-[(1S)-1-({[5-Chloro-2-(4-fluorophenoxy)pyridin-3-YL]carbonyl}amino)ethyl]benzoic acid	HCID 11683088	—
Product	5-Chloro-N-{(1S)-1-[4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}-2-(4-fluorophenoxy)nicotinamide	HCID 58905323	—

Reaction Steps

The title compound was prepared according to the procedure described in step 1 of Example 103 from 4-[(1S)-1-({[5-chloro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid (step 5 of Example 44) and 4-chlorobenzenesulfonamide: 1H-NMR (CDCl3) δ 8.51 (1H, d, J=2.6 Hz), 8.13 (1H, d, J=2.6 Hz), 8.16–8.03 (1H, m), 8.08 (2H, d, J=8.7 Hz), 7.75 (2H, d, J=8.2 Hz), 7.52 (2H, d, J=8.7 Hz), 7.43 (2H, d, J=8.2 Hz), 7.21–7.08 (4H, m), 5.39–5.24 (1H, m), 1.57 (3H, d, J=7.4 Hz); MS (ESI) m/z 588 (M+H)+, 586 (M−H)−.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07238714B2
Source dataset	uspto-grants-2007_07
ORD ID	ord-8cefeb1420724308b004ded8ef591f53
Source note	uspto-grants-2007_07