5-Methyl-2-pyridinesulfonamide → 5-Chloro-2-(4-fluorophenoxy)-N-{(1S)-1-[4-({[(5-methylpyridin-2-YL)sulfonyl]amino}carbonyl)phenyl]ethyl}nicotinamide

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 1 of Example 103 from 4-[(1S)-1-({[5-chloro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid (step 5 of Example 44) and 5-methylpyridine-2-sulfonamide: 1H-NMR (DMSO-d6) δ 8.95 (1H, d, J=8.6 Hz), 8.38 (1H, br.s), 8.26 (1H, d, J=2.6 Hz), 8.10 (1H, d, J=2.6 Hz), 7.92–7.70 (4H, m), 7.40 (2H, d, J=7.9 Hz), 7.30–7.23 (4H, m), 5.22–5.08 (1H, m), 2.34 (3H, s), 1.44 (3H, d, J=6.8 Hz); MS (ESI) m/z 569 (M+H)+, 567 (M−H)−.

Provenance & Evidence