3-Fluorobenzenesulfonamide → 5-Chloro-2-(4-fluorophenoxy)-N-{(1S)-1-[4-({[(3-fluorophenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}nicotinamide

関与物質

反応手順

The title compound was prepared according to the procedure described in step 1 of Example 103 from 4-[(1S)-1-({[5-chloro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid (step 5 of Example 44) and 3-fluorobenzenesulfonamide: 1H-NMR (CDCl3) δ 8.86 (1H, br.s), 8.51 (1H, d, J=2.6 Hz), 8.13 (1H, d, J=2.6 Hz), 8.14–8.08 (1H, m), 7.98–7.91 (1H, m), 7.89–7.81 (1H, m), 7.73 (2H, d, J=8.3 Hz), 7.61–7.50 (1H, m), 7.42 (2H, d, J=8.3 Hz), 7.40–7.30 (1H, m), 7.21–7.08 (4H, m), 5.37–5.24 (1H, m), 1.57 (3H, d, J=6.8 Hz); MS (ESI) m/z 572 (M+H)+, 570 (M−H)−.

情報源と証拠