m-Toluenesulphonamide → 5-Chloro-2-(4-fluorophenoxy)-N-{(1S)-1-[4-({[(3-methylphenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}nicotinamide

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 1 of Example 103 from 4-[(1S)-1-({[5-chloro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid (step 5 of Example 44) and 3-methylbenzenesulfonamide: 1H-NMR (CDCl3) δ 8.90 (1H, br.s), 8.51 (1H, d, J=2.6 Hz), 8.13 (1H, d, J=2.6 Hz), 8.09 (1H, d, J=7.2 Hz), 7.97–7.89 (2H, m), 7.74 (2H, d, J=8.3 Hz), 7.48–7.38 (4H, m), 7.20–7.05 (4H, m), 5.37–5.24 (1H, m), 2.44 (3H, s), 1.56 (3H, d, J=7.0 Hz); MS (ESI) m/z 568 (M+H)+, 566 (M−H)−.

Provenance & Evidence