(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 69418987, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5) and 5-chloro-2-(2,3-difluorophenoxy)benzoic acid (step 2): 1H-NMR (CDCl3) δ 8.15 (1H, d, J=2.6 Hz), 7.96 (2H, d, J=8.4 Hz), 7.62 (1H, d, J=7.4 Hz), 7.44–7.31 (3H, m), 7.14–7.00 (2H, m), 6.85 (1H, d, J=8.7 Hz), 6.81–6.68 (1H, m), 5.33 (1H, dq, J=7.4, 7.1 Hz), 3.90 (3H, s), 1.51 (3H, d, J=7.1 Hz); MS (ESI) m/z 446 (M+H)+, 444 (M−H)−.

Provenance & Evidence