(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 69415833, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5) and 5-chloro-2-(2,4-difluorophenoxy)benzoic acid (step 2): 1H-NMR (CDCl3) δ 8.16 (1H, d, J=2.6 Hz), 7.98 (2H, d, J=8.1 Hz), 7.80–7.70 (1H, m), 7.39 (2H, d, J=8.1 Hz), 7.34 (1H, dd, J=8.9, 2.6 Hz), 7.14–6.87 (3H, m), 6.73 (1H, d, J=8.9 Hz), 5.45–5.27 (1H, m), 3.90 (3H, s), 1.55 (3H, d, J=6.9 Hz); MS (ESI) m/z 446 (M+H)+, 444 (M−H)−.

Provenance & Evidence