HCID 55138670, compound → HCID 69415910, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5) and 5-chloro-2-(3,4-difluorophenoxy)benzoic acid (step 2): 1H-NMR (CDCl3) δ 8.16 (1H, d, J=2.8 Hz), 7.98–7.93 (2H, m), 7.60 (1H, d, J=7.4 Hz), 7.49 (1H, dd, J=8.7, 2.8 Hz), 7.35–7.29 (2H, m), 7.14 (1H, q, J=8.9 Hz), 6.88–6.78 (2H, m), 6.73–6.66 (1H, m), 5.31 (1H, dq, J=7.4, 6.9 Hz), 3.91 (3H, s), 1.51 (3H, d, J=6.9 Hz); MS (ESI) m/z 446 (M+H)+, 444 (M−H)−.

Provenance & Evidence