3-Chloro-5-fluorophenol → tert-Butyl 4-[(1S)-1-({[5-chloro-2-(3-chloro-5-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 45 from tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) and 3-chloro-5-fluorophenol: 1H-NMR (CDCl3) δ 8.55 (1H, d, J=2.6 Hz), 8.17 (1H, d, J=2.6 Hz), 7.97 (2H, d, J=8.4 Hz), 7.88–7.80 (1H, m), 7.40 (2H, d, J=8.4 Hz), 7.10–7.02 (1H, m), 7.00–6.94 (1H, m), 6.87–6.80 (1H, m), 5.43–5.27 (1H, m), 1.68–1.55 (12H, m); MS (ESI) m/z 505 (M+H)+, 503 (M−H)−.

Provenance & Evidence