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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1293290Generated: October 29, 2026

3,5-Difluorophenol → Methyl 5-chloro-2-(3,5-difluorophenoxy)benzoate

https://huagongshe.com/reaction/1293290

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DifluorophenolHCID 75928—
ReactantMethyl 5-chloro-2-fluorobenzoateHCID 21525433—
ProductMethyl 5-chloro-2-(3,5-difluorophenoxy)benzoateHCID 69415966—

Reaction Steps

The title compound was prepared according to the procedure described in step 1 of Example 67 from methyl 5-chloro-2-fluorobenzoate and 3,5-difluorophenol: 1H-NMR (CDCl3) δ 8.00–7.90 (1H, m), 7.55–7.47 (1H, m), 7.08–7.00 (1H, m), 6.60–6.35 (3H, m), 3.81 (3H, s).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07238714B2
Source datasetuspto-grants-2007_07
ORD IDord-049d606a86c4455a835273c7995cd696
Source noteuspto-grants-2007_07