3-Chloro-2-fluorophenol → Methyl 4-[(1S)-1-({[5-chloro-2-(3-chloro-2-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 3-chloro-2-fluorophenol: 1H-NMR (CDCl3) δ 8.55 (1H, d, J=2.7 Hz), 8.11 (1H, d, J=2.7 Hz), 8.03–8.00 (2H, m), 7.96–7.93 (1H, m), 7.45–7.35 (3H, m), 7.27–7.15 (2H, m), 5.43–5.35 (1H, m), 3.90 (3H, s), 1.61 (3H, d, J=7.0 Hz); MS (ESI) m/z 463 (M+H)+, 461 (M−H)−.

Provenance & Evidence