2-Chloro-4-methylphenol → HCID 69417518, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 2-chloro-4-methylphenol: 1H-NMR (CDCl3) δ 8.53 (1H, d, J=2.6 Hz), 8.20 (1H, d, J=7.4 Hz), 8.11 (1H, d, J=2.6 Hz), 8.01 (2H, d, J=8.4 Hz), 7.45 (2H, d, J=8.4 Hz), 7.37–7.31 (1H, m), 7.23–7.17 (2H, m), 5.39 (1H, dq, J=7.4, 6.9 Hz), 3.90 (3H, s), 2.40 (3H, s), 1.60 (3H, d, J=6.9 Hz); MS (ESI) m/z 459 (M+H)+, 457 (M−H)−.

Provenance & Evidence