(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 69417560, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-(2,5-difluorophenoxy)benzoic acid (step 2) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.16 (1H, d, J=2.6 Hz), 7.95 (2H, d, J=8.2 Hz), 7.60 (1H, d, J=7.4 Hz), 7.45–7.32 (3H, m), 7.25–7.13 (1H, m), 6.97–6.82 (2H, m), 6.80–6.67 (1H, m), 5.33 (1H, dq, J=7.4, 6.9 Hz), 3.90 (3H, s), 1.53 (3H, d, J=6.9 Hz); MS (ESI) m/z 446 (M+H)+, 444 (M−H)−.

Provenance & Evidence