3-Fluorophenol → 5-Cyano-2-(3-fluorophenoxy)benzoic acid

HRID 1293319Notes

Reaction equation

HRID 1293319 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6](F)=[C:7]([CH:12]=1)[C:8]([O:10]C)=[O:9])#[N:2].[F:14][C:15]1[CH:16]=[C:17]([OH:21])[CH:18]=[CH:19][CH:20]=1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([F:14])[CH:16]=2)=[C:7]([CH:12]=1)[C:8]([OH:10])=[O:9])#[N:2]

Participants

3

Reactant 2

HCID 97433-FluorophenolHCID 55265274Methyl 5-cyano-2-fluorobenzoate

Product 1

HCID 694189615-Cyano-2-(3-fluorophenoxy)benzoic acid

Procedure

The title compound was prepared according to the procedure described in step 1 and 2 of Example 67 from methyl 5-cyano-2-fluorobenzoate and 3-fluorophenol: 1H-NMR (CDCl3) δ 8.36 (1H, s), 7.73 (1H, m), 7.39 (1H, m), 7.00–6.78 (4H, m).

Sources & evidence

ORD record
ord-d0658b06d01d4f96930481f87d1df9dd
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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