tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate → 4-[(1S)-1-({[5-Chloro-2-(4-pyridin-4-ylphenoxy)pyridin-3-YL]carbonyl}amino)ethyl]benzoic acid

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 45 from tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) and 4-pyridin-4-ylphenol (J. Med. Chem. 2003, 46, 3709): 1H-NMR (CDCl3) δ 8.68 (2H, d, J=6.0 Hz), 8.57 (1H, d, J=2.6 Hz), 8.16 (1H, d, J=2.6 Hz), 8.10 (1H, d, J=7.9 Hz), 7.96 (2H, d, J=8.2 Hz), 7.73 (2H, d, J=8.7 Hz), 7.52 (2H, d, J=6.0 Hz), 7.41 (2H, d, J=8.2 Hz), 7.29 (2H, d, J=8.7 Hz), 5.38 (1H, m), 1.60 (3H, d, J=7.5 Hz), 1.57 (9H, s).

Provenance & Evidence