Sodium Hydroxide → HCID 15023289, compound

Participants

Reaction Steps

To an ethanol solution (40 ml) of 2.60 g (8.1 mmol) of ethyl 5-tridecylpyrrole-3-carboxylate prepared in Example 5 was added 10 ml of an aqueous solution containing 1.40 g (33 mmol) of sodium hydroxide. The mixture was heated under reflux for 36 hours. After removing the ethanol, the mixture was acidified with hydrochloric acid, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give crystals, which were purified by subjecting them to column chromatography over silica gel (eluent: ethyl acetate/hexane=1/2) to obtain 2.04 g (86% yield) of pure 5-tridecylpyrrole-3-carboxylic acid, m.p. 82°-84° C.

Provenance & Evidence