(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 69419038, compound

HRID 1293330Notes

Reaction equation

HRID 1293330 reaction equation
[F:1][C:2]1[C:10]([F:11])=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([O:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:3]=1.Cl.[NH2:21][C@H:22]([C:24]1[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=1)[CH3:23]>>[F:1][C:2]1[C:10]([F:11])=[CH:9][C:5]([C:6]([NH:21][C@H:22]([C:24]2[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=2)[CH3:23])=[O:8])=[C:4]([O:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 69418038HCID 69418038, compound

Product 1

HCID 69419038HCID 69419038, compound

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 1 from 4,5-difluoro-2-(4-fluorophenoxy)benzoic acid (step 1) and methyl 4-[(1S)-1-aminoethyl]benzoate (step 3 of Example 5): MS (ESI) m/z 430 (M+H)+, 428 (M−H)−.

Sources & evidence

ORD record
ord-b3adacfa526244c0b36419195f1fdcac
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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