反应详情

A solution (1 ml) of 2N sodium hydroxide was added to an ethanol solution (5 ml) of 0.22 g (0.69 mmol) of methyl 4-tetradecylpyrrole-2-carboxylate prepared in Example 9 and heated under reflux for 13 hours. Water was added to the resulting mixture, and then washed with ether. After acidifying the aqueous layer with hydrochloric acid, the mixture was extracted with ether and dried over anhydrous magnesium sulfate. The removal of the solvent afforded 0.19 g (95% yield) of 4-tetradecylpyrrole-2-carboxylic acid, m.p. 148°-150 ° C.

1. temperatureheated
2. temperatureunder reflux for 13 hours
3. washwashed with ether
4. extractionthe mixture was extracted with ether
5. dry with materialdried over anhydrous magnesium sulfate
6. customThe removal of the solvent